Kakhktsyan Sh S, Moshetova L K, Turkina K I, Sychev D A
Russian Medical Academy of Postgraduate Education, Ministry of Health of the Russian Federation, 2/1 Barrikadnaya St., Moscow, Russian Federation, 125993.
Vestn Oftalmol. 2016;132(4):94-97. doi: 10.17116/oftalma2016132494-97.
In recent years, more and more attention has been paid to the role of polymorphisms in genes that code for the components of vitamin K cycle in the development of retinal vascular occlusion. Vitamin K serves as a cofactor for a number of blood coagulation factors, namely, factor II, VII, IX, and X, and also for anticoagulation proteins C and S. According to the literature, 1639G4A polymorphism of the vitamin K epoxide reductase complex subunit 1 gene (VKORC1) is likely to be a new risk factor of retinal vascular occlusion.
近年来，编码维生素K循环成分的基因多态性在视网膜血管阻塞发生发展中的作用越来越受到关注。维生素K作为多种凝血因子的辅因子，即凝血因子II、VII、IX和X，也是抗凝蛋白C和S的辅因子。据文献报道，维生素K环氧化物还原酶复合体亚基1基因（VKORC1）的1639G4A多态性可能是视网膜血管阻塞的一个新的危险因素。
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