透析期间营养能否改善血液透析患者的难治性贫血？

Could intradialytic nutrition improve refractory anaemia in patients undergoing haemodialysis?

作者信息

Thabet Ahmad F, Moeen Sawsan M, Labiqe Mohammed O, Saleh Medhat A

机构信息

Faculty of Medicine Assiut University, Department of Internal Medicine, Assiut, Egypt.

Faculty of Medicine, Public Health and Community Medicine, Assiut University, Assiut, Egypt.

出版信息

J Ren Care. 2017 Sep;43(3):183-191. doi: 10.1111/jorc.12206. Epub 2017 Jun 21.

DOI:10.1111/jorc.12206

PMID:28636166

Abstract

BACKGROUND

This prospective randomised study was designed to evaluate the efficacy of intradialytic parenteral nutrition (IDPN) therapy in malnourished patients with refractory anaemia.

METHODS

Forty patients who were malnourished with a BMI not greater than 23 (17-23) kg/m , undergoing regular HD were included. Of those, 20 patients received 500-1000 ml of IDPN at a rate of 250-300 ml/h at each HD session three days per week for six consecutive months. The other 20 patients did not receive IDPN infusion. The malnutrition inflammation score (MIS) and haematological parameters were recorded at baseline and after three and six months.

RESULTS

Mean haemoglobin levels, BMI and serum albumin were significantly increased while MIS was significantly decreased after the 3rd and 6th months of IDPN.

CONCLUSION

IDPN has a good role in improving refractory anaemia by significantly increasing haemoglobin levels, body weight, and serum albumin levels. The intervention also significantly decreases the MIS of patients.

摘要

背景

本前瞻性随机研究旨在评估透析期间肠外营养（IDPN）治疗对营养不良的难治性贫血患者的疗效。

方法

纳入40例营养不良、体重指数（BMI）不超过23（17 - 23）kg/m²且接受规律血液透析（HD）的患者。其中，20例患者在每周3天的每次HD治疗期间，以250 - 300 ml/h的速度接受500 - 1000 ml的IDPN治疗，持续6个月。另外20例患者未接受IDPN输注。在基线、3个月和6个月时记录营养不良炎症评分（MIS）和血液学参数。