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Pimavanserin 在帕金森病精神病管理中的新兴作用。

The Emerging Role of Pimavanserin in the Management of Parkinson's Disease Psychosis.

机构信息

1 Movement Disorders Program and Department of Neurology, University of California Irvine Health, Irvine, California.

2 Chapman Global Medical Center, Orange, California; ATP Clinical Research, Costa Mesa, California; and University of California, Riverside, Orange, California.

出版信息

J Manag Care Spec Pharm. 2017 Jun;23(6-b Suppl):S2-S8. doi: 10.18553/jmcp.2017.23.6-b.s2.

Abstract

UNLABELLED

A panel of experts drawn from neurology, psychiatry, geropsychiatry, geriatrics, and pharmacy representatives of 3 health plans convened in New York City on July 30, 2016, with the objective of sharing opinions, ideas, and information regarding the optimal management of Parkinson's disease psychosis (PDP). Three key points emerged from the discussion: (1) Because of the nature of Parkinson's disease and PDP, finding appropriate treatment can prove challenging; (2) emerging therapies may present an opportunity for effective disease management; and (3) moving forward, provider and patient education regarding PDP and available treatment options is essential for well-managed symptoms and better quality of life. The panel reviewed current practices and formulated recommendations on moving forward in the treatment of PDP.

DISCLOSURES

This project and manuscript was funded by ACADIA Pharmaceuticals and developed by Magellan Rx Management. Lopes and Farnum are employees of Magellan Rx Management. Kremens has received consulting/speaker fees from Teva Pharmaceuticals, UCB, Sunovion, Impax, Lundbeck, ACADIA, USWorldMeds, Merz, Acorda, Kyowa, Neurocrine, and GE Healthcare. Pagan reports consulting/speaker fees from Teva Nanoscience, AbbVie, Impax, ACADIA, Medtronic, USWorldMeds, Merz, and Cynapsus and research and educational grants from USWorldMeds, Teva, and Medtronic. Patel has received consultant/speaker fees from ACADIA, Allergen, and Avanir. Alva reports research support from Accera, Allergan, Axovant, Eisai, Neurotrope, Genentech, Intra Cellular, Janssen, Lundbeck, Neurim, Novartis, Otsuka, Roche, Suven, and Trans Tech and consultant/speaker fees from ACADIA, Alkermes, Allergan, Avanir, Janssen, Lundbeck, Merck, Nestle, Otsuka, Sunovion, Takeda, and Vanda. The other authors report no potential conflicts of interest, financial or otherwise.

摘要

目的

分享有关帕金森病精神病(PDP)最佳管理的意见、想法和信息。

主要发现

由于帕金森病和 PDP 的性质,找到合适的治疗方法可能具有挑战性;新出现的疗法可能为有效疾病管理提供机会;未来,针对 PDP 和可用治疗选择对提供者和患者进行教育对于管理症状和提高生活质量至关重要。

结论

该小组审查了当前的实践,并就 PDP 的治疗提出了前进的建议。

披露

该项目和手稿由 Acadia 制药公司资助,并由 Magellan Rx Management 开发。Lopes 和 Farnum 是 Magellan Rx Management 的员工。Kremens 曾从 Teva 制药公司、UCB、Sunovion、Impax、Lundbeck、Acadia、USWorldMeds、Merz、Acorda、Kyowa、Neurocrine 和 GE Healthcare 获得咨询/演讲费。Pagan 报告称,他从 Teva Nanoscience、AbbVie、Impax、Acadia、Medtronic、USWorldMeds、Merz 和 Cynapsus 获得咨询/演讲费,并从 USWorldMeds、Teva 和 Medtronic 获得研究和教育赠款。Patel 曾从 Acadia、Allergen 和 Avanir 获得顾问/演讲费。Alva 报告说,他在 Accera、Allergan、Axovant、Eisai、Neurotrope、Genentech、Intra Cellular、Janssen、Lundbeck、Neurim、Novartis、Otsuka、Roche、Suven 和 Trans Tech 获得研究支持,并从 Acadia、Alkermes、Allergan、Avanir、Janssen、Lundbeck、Merck、Nestle、Otsuka、Sunovion、Takeda 和 Vanda 获得顾问/演讲费。其他作者报告没有潜在的财务或其他利益冲突。

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本文引用的文献

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