醛固酮调节肾集合管中钠钾 atp 酶的β-3 亚单位的表达。
Mineralocorticoids modulate the expression of the β-3 subunit of the Na, K-ATPase in the renal collecting duct.
机构信息
a Instituto de Ciencias Biomédicas, Facultad de Medicina, Universidad de Chile , Santiago , Chile.
b Instituto de Química, Pontificia Universidad Católica de Valparaíso , Valparaíso , Chile.
出版信息
Channels (Austin). 2017 Sep 3;11(5):388-398. doi: 10.1080/19336950.2017.1344800. Epub 2017 Jun 21.
Renal sodium reabsorption depends on the activity of the Na,K-ATPase α/β heterodimer. Four α (α) and 3 β (β) subunit isoforms have been described. It is accepted that renal tubule cells express α/β dimers. Aldosterone stimulates Na,K-ATPase activity and may modulate α/β expression. However, some studies suggest the presence of β in the kidney. We hypothesized that the β isoform of the Na,K-ATPase is expressed in tubular cells of the distal nephron, and modulated by mineralocorticoids. We found that β is highly expressed in collecting duct of rodents, and that mineralocorticoids decreased the expression of β. Thus, we describe a novel molecular mechanism of sodium pump modulation that may contribute to the effects of mineralocorticoids on sodium reabsorption.
肾钠重吸收取决于 Na，K-ATPase α/β 异二聚体的活性。已经描述了四种 α (α) 和 3 β (β) 亚基同工型。人们普遍认为肾小管细胞表达 α/β 二聚体。醛固酮刺激 Na，K-ATPase 活性并可能调节 α/β 表达。然而，一些研究表明 β 存在于肾脏中。我们假设 Na，K-ATPase 的 β 同工型在远曲小管的管状细胞中表达，并受盐皮质激素调节。我们发现 β 在啮齿动物的集合管中高度表达，而盐皮质激素降低了 β 的表达。因此，我们描述了一种钠泵调节的新分子机制，它可能有助于盐皮质激素对钠重吸收的作用。
Zotero 插件