Kraal J H, Wong P H
Pharmacol Ther Dent. 1978;3(2-4):111-5.
Chlorhexidine digluconate was administered to rats by incorporating the drug in drinking water and by regular gastric intubation. Incorporating the drug in the drinking water resulted in feed and water rejection. Relatively high doses (30 mg/day) could be administered over a period of 30 to 45 days without apparent effect on feed and water intake and growth. The total number of bacteria as well as the number of colony-forming units from cecal samples were determined. Chlorhexidine intake did not reduce the cultivable or total intestinal flora.
通过将葡萄糖酸洗必泰加入饮用水中以及定期进行胃插管的方式给大鼠用药。将药物加入饮用水中会导致大鼠拒食和拒水。在30至45天的时间内可以给予相对高剂量（30毫克/天），而对食物和水的摄入量以及生长没有明显影响。测定了盲肠样本中的细菌总数以及菌落形成单位数。洗必泰的摄入并未减少可培养的或总的肠道菌群。
