Zhang Zongfeng, Fan Qing, Zhu Yajing, Tan Ling, Chen Yongjun, Gao Rui, Zhang Haiyin, Li Yao, Xiao Zeping
Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Shanghai Jiao Tong University Institute of Social Cognitive and Behavioral Sciences, Shanghai, China.
Neurosci Lett. 2017 Jul 27;654:86-92. doi: 10.1016/j.neulet.2017.06.026. Epub 2017 Jun 19.
Cortico-striato-thalamo-cortical (CSTC) circuit has been implicated in OCD pathophysiology by converging neuroimaging findings. The anterior cingulate cortex (ACC), as an important part within CSTC circuit, plays a critical role in OCD etiology. The ACC can be divided into dorsal and rostral parts anatomically, which are involved in cognitive process and emotional function, respectively. However, the diverse function of intrinsic signals from dorsal and rostral ACC regions remains unclear in OCD study. In this work, we applied resting-state functional magnetic resonance imaging (rs-fMRI) technology to investigate and differentiate the functional connectivity (FC) characteristics between dACC and rACC in unmedicated OCD patients. Also, the correlation between the altered FC and clinical symptom severity was analyzed. Decreased FC of rACC-DLPFC and increased FC between dACC and caudate were found. Moreover, the altered dACC-caudate FC was positively correlated with total Y-BOCS and compulsion score in OCD patients. Our findings implied the crossed function of dorsal and rostral circuits in the pathophysiologic mechanism of OCD. The dorsal cingulate-striatum functional pathway served as a potential biomarker for OCD symptomatology and merits further investigations.
皮质-纹状体-丘脑-皮质（CSTC）环路已通过多项神经影像学研究结果被证实与强迫症的病理生理学有关。前扣带回皮质（ACC）作为CSTC环路的重要组成部分，在强迫症的病因学中起着关键作用。ACC在解剖学上可分为背侧和喙侧部分，分别参与认知过程和情感功能。然而，在强迫症研究中，来自背侧和喙侧ACC区域的内在信号的不同功能仍不清楚。在这项研究中，我们应用静息态功能磁共振成像（rs-fMRI）技术来研究和区分未服药的强迫症患者背侧ACC（dACC）和喙侧ACC（rACC）之间的功能连接（FC）特征。此外，还分析了FC改变与临床症状严重程度之间的相关性。研究发现rACC与背外侧前额叶皮质（DLPFC）之间的FC降低，而dACC与尾状核之间的FC增加。此外，强迫症患者中dACC与尾状核之间改变的FC与Y-BOCS总分及强迫症状评分呈正相关。我们的研究结果提示背侧和喙侧环路在强迫症病理生理机制中存在交叉功能。背侧扣带回-纹状体功能通路可能是强迫症症状学的一个潜在生物标志物，值得进一步研究。
