Freed W J, Ghoz E H, Crump S
Neurobehav Toxicol Teratol. 1985 May-Jun;7(3):275-8.
Glutamic acid di-tert butyl ester (GTBE) was found to have a pronounced convulsant effect in mice and rats, producing recurrent clonic convulsions combined with postural and respiratory disturbances in a dosage of 0.5 mmol/kg (148 mg/kg). Tert-butyl ester derivatives of aspartic acid and alanine, and glutamic acid gamma-benzyl ester did not produce seizures. Various other glutamate esters, such as glutamic acid diethyl ester and glutamic acid dimethyl ester, have previously been found to have anticonvulsant effects, and also do not induce seizures. It is suggested that glutamic acid di-tert butyl ester may have specific pharmacological properties which differ from those of other known convulsant drugs.
已发现谷氨酸二叔丁酯（GTBE）对小鼠和大鼠有明显的惊厥作用，以0.5毫摩尔/千克（148毫克/千克）的剂量给药时会产生反复阵挛性惊厥，并伴有姿势和呼吸紊乱。天冬氨酸和丙氨酸的叔丁酯衍生物以及谷氨酸γ-苄酯不会引发癫痫发作。先前已发现各种其他谷氨酸酯，如谷氨酸二乙酯和谷氨酸二甲酯具有抗惊厥作用，也不会诱发癫痫发作。有人提出，谷氨酸二叔丁酯可能具有与其他已知惊厥药物不同的特定药理特性。
