Maurin Y, Berger B, Le Saux F, Gay M, Baumann N
Neurosci Lett. 1985 Jun 24;57(3):313-8. doi: 10.1016/0304-3940(85)90511-7.
Noradrenergic cell bodies in the locus ceruleus of the convulsive mutant quaking mouse and the control of the same strain were visualized using histofluorescence and tyrosine hydroxylase-like immunoreactivity. Cell counts performed with the two techniques gave closely similar results within each strain, indicating a 50% increase in the number of noradrenergic neurons in the midportion of the mutants' locus ceruleus when compared to the controls. This result gives histological support to the increased noradrenergic neurotransmission previously described in the brain of this mutant. Thus, the abnormally high activity of the noradrenergic system appears to be a primary effect of the mutation, associated with the convulsions of this animal model of epilepsy.
利用组织荧光法和酪氨酸羟化酶样免疫反应，对惊厥突变型颤抖小鼠蓝斑中的去甲肾上腺素能细胞体以及同一品系的对照小鼠进行了可视化观察。用这两种技术进行的细胞计数在每个品系中都得出了非常相似的结果，表明与对照相比，突变型小鼠蓝斑中部去甲肾上腺素能神经元数量增加了50%。这一结果为先前在该突变型小鼠大脑中描述的去甲肾上腺素能神经传递增加提供了组织学支持。因此，去甲肾上腺素能系统异常高的活性似乎是该突变的主要效应，与这种癫痫动物模型的惊厥有关。
