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[急性肠梗阻患者的微量元素稳态纠正与氧化应激]

[Microelemental homeostasis correction of and oxidative stress in patients with acute intestinal obstruction].

作者信息

Scripko V D, Kovalenko A L, Zaplutonov V A

机构信息

Ivano-Frankovsk National Medical University, Ivano-Frankovsk, Ukrain.

Toxicology Institute of FMBA, St. Petersburg.

出版信息

Khirurgiia (Mosk). 2017(6):55-59. doi: 10.17116/hirurgia2017655-59.

Abstract

AIM

To improve the results of treatment of patients with acute small bowel obstruction.

MATERIAL AND METHODS

The research is based on the results of a comprehensive survey 202 people with acute small bowel obstruction. Reamberin was used in 102 patients treatment.

RESULTS

It was established that metalloenzymes take an active part in the formation of endotoxemia in people with acute small bowel obstruction. Also, in patients as a result of an imbalance between oxidant and antioxidant systems, accumulated a significant amount of lipid peroxidation products, along with it a decrease activity of enzymes of antioxidant system. reamberin application in complex treatment of acute small bowel obstruction provided the reduction in the time correction of oxidative stress by preventing the growth and activity of lipid peroxidation products with simultaneous stimulation of the antioxidant system and contributed to the normalization of microelement homeostasis.

摘要

目的

提高急性小肠梗阻患者的治疗效果。

材料与方法

该研究基于对202例急性小肠梗阻患者的综合调查结果。102例患者在治疗中使用了雷姆贝林。

结果

已确定金属酶在急性小肠梗阻患者内毒素血症的形成中起积极作用。此外,由于氧化和抗氧化系统之间的失衡,患者体内积累了大量脂质过氧化产物,同时抗氧化系统的酶活性降低。雷姆贝林应用于急性小肠梗阻的综合治疗,通过防止脂质过氧化产物的增长和活性,同时刺激抗氧化系统,减少了氧化应激的纠正时间,并有助于微量元素稳态的正常化。

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