中脑边缘和纹状体多巴胺受体超敏反应：L-脯氨酰-L-亮氨酰-甘氨酰胺（PLG）的预防和逆转作用。

Mesolimbic and striatal dopamine receptor supersensitivity: prophylactic and reversal effects of L-prolyl-L-leucyl-glycinamide (PLG).

作者信息

Chiu P, Rajakumar G, Chiu S, Johnson R L, Mishra R K

出版信息

Peptides. 1985 Mar-Apr;6(2):179-83. doi: 10.1016/0196-9781(85)90036-1.

Abstract

Functional supersensitivity of mesolimbic and striatal dopamine receptors has been suggested to contribute to the pathogenesis of schizophrenia and tardive dyskinesia. Using the rodent model of chronic administration of the neuroleptic haloperidol, we investigated the possible desensitizing effects of a tripeptide structurally unrelated to dopamine agonists, L-prolyl-L-leucyl-glycinamide (PLG) on mesolimbic and striatal dopaminergic receptor supersensitivity. Administration of PLG either prior to or after chronic haloperidol, inhibited the supersensitivity of dopamine receptors. The results have implications for pharmacological intervention in preventing tardive dyskinesia and relapse psychosis of schizophrenia.

摘要

中脑边缘和纹状体多巴胺受体的功能性超敏反应被认为与精神分裂症和迟发性运动障碍的发病机制有关。利用长期给予抗精神病药物氟哌啶醇的啮齿动物模型，我们研究了一种与多巴胺激动剂结构无关的三肽L-脯氨酰-L-亮氨酰-甘氨酰胺（PLG）对中脑边缘和纹状体多巴胺能受体超敏反应的可能脱敏作用。在长期给予氟哌啶醇之前或之后给予PLG，均可抑制多巴胺受体的超敏反应。这些结果对预防迟发性运动障碍和精神分裂症复发精神病的药物干预具有重要意义。