Yehuda S, Sheleff P
Peptides. 1985 Mar-Apr;6(2):189-92. doi: 10.1016/0196-9781(85)90038-5.
The neuropharmacological basis for d-amphetamine induced paradoxical behavioral thermoregulation remains unclear. This study examined thermoregulatory behavior of rats in a runway device that housed a heat source at one end and in which locomotion along the length of the runway could be observed. Sprague Dawley rats were pretreated with IP injections of saline, beta-endorphin, MIF-1, or alpha-MSH, with a repeat injection after 30 min. In a second experiment, d-amphetamine was administered as the repeat drug for all Ss. The results showed clear differences for heat-source-on vs. heat-source off. All peptides induced hypermotility, although no differentiated effects for the peptides on d-amphetamine induced paradoxical behavioral thermoregulation were found. These findings are discussed in light of the theoretical possibilities that: (a) a ceiling effect exists; (b) there are separate control systems for maintaining body temperature and another for behavioral thermoregulatory responses, and (c) other neurotransmitters may be involved in such induced paradoxical behavioral thermoregulation.
右旋苯丙胺诱发反常行为性体温调节的神经药理学基础仍不清楚。本研究在一个跑道装置中检测了大鼠的体温调节行为，该装置一端设有热源，可观察到大鼠沿跑道长度的运动情况。对斯普拉格-道利大鼠腹腔注射生理盐水、β-内啡肽、促黑素细胞激素释放抑制因子-1（MIF-1）或α-促黑素（α-MSH）进行预处理，30分钟后重复注射。在第二个实验中，对所有受试对象再次注射右旋苯丙胺作为药物。结果显示，热源开启和热源关闭时存在明显差异。所有肽类均诱发了运动亢进，不过未发现肽类对右旋苯丙胺诱发的反常行为性体温调节有不同影响。根据以下理论可能性对这些发现进行了讨论：（a）存在天花板效应；（b）存在分别用于维持体温和行为性体温调节反应的独立控制系统；以及（c）其他神经递质可能参与这种诱发的反常行为性体温调节。
