Department of Neurology, Chinese PLA General Hospital, Beijing, 100853, China.
Sci Rep. 2017 Jun 21;7(1):3960. doi: 10.1038/s41598-017-04060-6.
Functional connectivity (FC) has been used to investigate the pathophysiology of migraine. We aimed to identify atypical FC between the periaqueductal gray (PAG) and other brain areas in rats induced by repeated meningeal nociception. The rat model was established by infusing an inflammatory soup (IS) through supradural catheters in conscious rats. Quiescent and face-grooming behaviors were observed to assess nociceptive behavior. FC analysis seeded on the PAG was performed on rats 21 days after IS infusion. The rats exhibited nociceptive behavior correlates of human behaviors associated with migraine after IS infusion. The PAG showed increased FC with the prefrontal cortex, cingulate gyrus, and motor cortex but decreased FC with the basal ganglia, dorsal lateral thalamus, internal capsule and prelimbic cortex in the rat model. The atypical FC of the PAG with brain regions in the rat model that are involved in nociception, somatosensory processing, emotional processing, and pain modulation are consistent with the clinical data from migraineurs, indicate that resting-state FC changes in migraine patients may be a consequence of headache attacks, and further validate this rat model of chronic migraine.
功能连接（FC）已被用于研究偏头痛的病理生理学。我们旨在确定反复脑膜疼痛诱导的大鼠中导水管周围灰质（PAG）与其他脑区之间的非典型 FC。通过在清醒大鼠的硬脑膜导管中输注炎性汤（IS）建立大鼠模型。观察静止和面部梳理行为以评估疼痛行为。在 IS 输注 21 天后，对大鼠进行基于 PAG 的 FC 分析。IS 输注后，大鼠表现出与人类偏头痛相关行为相关的疼痛行为。与基底神经节、外侧背丘脑、内囊和前扣带皮层相比，PAG 与前额叶皮层、扣带回和运动皮层的 FC 增加，但与基底神经节、外侧背丘脑、内囊和前扣带皮层的 FC 减少。大鼠模型中 PAG 与参与疼痛、躯体感觉处理、情绪处理和疼痛调节的脑区的非典型 FC 与偏头痛患者的临床数据一致，表明偏头痛患者的静息状态 FC 变化可能是头痛发作的结果，并进一步验证了这种慢性偏头痛大鼠模型。
