Schiekofer Stephan, Kleber Marcus E, Maerz Winfried, Rasche Franz M, Schneider Jochen G
Geriatric Medicine, University of Regensburg, Regensburg, Germany.
Vth Department of Medicine, Mannheim Medical Faculty, Heidelberg University, Mannheim, Germany.
Int J Endocrinol. 2017;2017:2869090. doi: 10.1155/2017/2869090. Epub 2017 May 30.
Hepatic lipase (HL) functions as a lipolytic enzyme that hydrolyzes triglycerides and phospholipids present in circulating plasma lipoproteins. Plasma HL activity is known to be regulated by hormonal and metabolic factors, but HL responsiveness to insulin as well as its role in modulating atherosclerotic risk is still controversial. We investigated on the influence of a known polymorphism in the neurotransmitter neuropeptide Y (NPY) on HL activity in two different cohorts consisting of diabetic and nondiabetic patients. HL activity was 24% and 34% higher on nondiabetic and diabetic subjects in the presence of the 7Pro allele in NPY, respectively. The presence of the 7Pro allele was an independent predictor of HL activity in multivariate analyses in both cohorts. These data suggest a regulatory effect of NPY on HL activity. Among carriers of the 7Pro allele, we also found a statistically significant lower absolute number of infarctions compared to noncarriers ( < 0.05) and a nonsignificant trend towards less myocardial infarction in the 7Pro allele diabetic carriers ( = 0.085). In conclusion, the common 7Pro allele in NPY was associated with higher HL activity in nondiabetic and diabetic subjects and its presence seems to coincide with a lower frequency of certain cardiovascular events.
肝脂肪酶（HL）作为一种脂解酶，可水解循环血浆脂蛋白中的甘油三酯和磷脂。已知血浆HL活性受激素和代谢因素调节，但HL对胰岛素的反应性及其在调节动脉粥样硬化风险中的作用仍存在争议。我们在由糖尿病患者和非糖尿病患者组成的两个不同队列中，研究了神经递质神经肽Y（NPY）中一种已知多态性对HL活性的影响。在NPY存在7Pro等位基因的情况下，非糖尿病和糖尿病受试者的HL活性分别高出24%和34%。在两个队列的多变量分析中，7Pro等位基因的存在是HL活性的独立预测因子。这些数据表明NPY对HL活性有调节作用。在7Pro等位基因携带者中，我们还发现与非携带者相比，梗死的绝对数量在统计学上显著更低（<0.05），并且在7Pro等位基因糖尿病携带者中，心肌梗死减少的趋势不显著（=0.085）。总之，NPY中常见的7Pro等位基因与非糖尿病和糖尿病受试者中较高的HL活性相关，其存在似乎与某些心血管事件的较低发生率一致。
