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长链非编码RNA CCAT2作为预测癌症患者临床结局的潜在新型生物标志物：一项荟萃分析。

Long Noncoding RNA CCAT2 as a Potential Novel Biomarker to Predict the Clinical Outcome of Cancer Patients: A Meta-Analysis.

作者信息

Tan Juan, Hou Yi-Chao, Fu Lin-Na, Wang Yun-Qian, Liu Qian-Qian, Xiong Hua, Chen Ying-Xuan, Fang Jing-Yuan

机构信息

Division of Gastroenterology and Hepatology, Key Laboratory of Gastroenterology and Hepatology, Ministry of Health, State Key Laboratory for Oncogenes and Related Genes, Renji Hospital, School of Medicine, Shanghai Jiao Tong University.

出版信息

J Cancer. 2017 Jun 1;8(8):1498-1506. doi: 10.7150/jca.18626. eCollection 2017.

DOI:10.7150/jca.18626
PMID:28638466
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5479257/
Abstract

Colon Cancer-Associated Transcript 2 (CCAT2) has been demonstrated associated with clinical outcomes in various tumors. However, the results from each study were unfortunately insufficient and not completely consistent. Therefore, we conduct a systematic meta-analysis to evaluate the value for a feasible biomarker for metastasis and prognosis. A meta-analysis was performed using data obtained through a systematic search of PubMed, EMBASE, Cochrane Library, China National Knowledge Infrastructure, Wanfang database and VIP database. The pooled odds ratio (OR) and hazard ratio (HR) with 95% Confidence interval (CI ) using random-effect were used to identify the relationship of CCAT2 with clinical outcome of cancer patients. Subgroup analysis and sensitivity analysis were performed. A total of 867 patients from eight studies were finally included. Patients with high CCAT2 expression underwent an increased risk of lymph node metastasis (LNM) (OR=3.09, 95% CI: 1.53-6.26) and distant metastasis (DM) (OR=7.70, 95% CI: 3.26-18.17). CCAT2 was also significantly correlated with overall survival (OS) (HR=2.19, 95%CI: 1.70-2.82) and progression-free survival (PFS) (HR=2.59, 95% CI: 1.78-3.76). Moderate heterogeneity was observed in meta-analysis for LNM. However, the results remained robust in multiple sensitivity analyses. High expression of CCAT2 was linked with poor clinical outcome. CCAT2 can serve as a potential molecular marker for prognosis in different types of cancers.

摘要

结肠癌相关转录本2（CCAT2）已被证明与多种肿瘤的临床结局相关。然而，遗憾的是，每项研究的结果都不充分且不完全一致。因此，我们进行了一项系统的荟萃分析，以评估其作为转移和预后可行生物标志物的价值。使用通过系统检索PubMed、EMBASE、Cochrane图书馆、中国知网、万方数据库和维普数据库获得的数据进行荟萃分析。采用随机效应模型合并95%置信区间（CI）的比值比（OR）和风险比（HR），以确定CCAT2与癌症患者临床结局的关系。进行了亚组分析和敏感性分析。最终纳入了八项研究中的867例患者。CCAT2高表达患者发生淋巴结转移（LNM）的风险增加（OR=3.09，95%CI：1.53-6.26）和远处转移（DM）的风险增加（OR=7.70，95%CI：3.26-18.17）。CCAT2还与总生存期（OS）（HR=2.19，95%CI：1.70-2.82）和无进展生存期（PFS）（HR=2.59，95%CI：1.78-3.76）显著相关。荟萃分析中观察到LNM存在中度异质性。然而，在多次敏感性分析中结果仍然稳健。CCAT2高表达与不良临床结局相关。CCAT2可作为不同类型癌症预后的潜在分子标志物。

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The up-regulation of long non-coding RNA CCAT2 indicates a poor prognosis for prostate cancer and promotes metastasis by affecting epithelial-mesenchymal transition.长链非编码RNA CCAT2的上调预示着前列腺癌的预后不良，并通过影响上皮-间质转化促进转移。
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