长链非编码RNA MALAT-1是多种癌症中的一种新型生物标志物：基于GEO数据库和文献的荟萃分析
The Long Noncoding RNA MALAT-1 is A Novel Biomarker in Various Cancers: A Meta-analysis Based on the GEO Database and Literature.
作者信息
Wang Yumin, Xue Dan, Li Yuwei, Pan Xuya, Zhang Xueying, Kuang Biao, Zhou Ming, Li Xiaoling, Xiong Wei, Li Guiyuan, Zeng Zhaoyang, Yang Tubao
机构信息
1. Key Laboratory of Carcinogenesis of Ministry of Health, Xiangya Hospital, Central South University, Changsha, Hunan 410078, China; 2. Key Laboratory of Carcinogenesis and Cancer Invasion of Ministry of Education, Cancer Research Institute, Central South University, Changsha, Hunan 410078, China.
1. Key Laboratory of Carcinogenesis of Ministry of Health, Xiangya Hospital, Central South University, Changsha, Hunan 410078, China; 2. Key Laboratory of Carcinogenesis and Cancer Invasion of Ministry of Education, Cancer Research Institute, Central South University, Changsha, Hunan 410078, China; 3. Hunan Key Laboratory of Nonresolving Inflammation and Cancer, Disease Genome Research Center, The Third Xiangya Hospital, Central South University, Changsha, Hunan 410013, China.
出版信息
J Cancer. 2016 May 20;7(8):991-1001. doi: 10.7150/jca.14663. eCollection 2016.
BACKGROUND
MALAT-1 is significantly overexpressed in various cancers, suggesting that it might be a potential biomarker of cancer.
METHODS
A meta-analysis was performed using microarray data obtained via the Affymetrix Human Genome U133 Plus 2.0 platform found in the Gene Expression Omnibus (GEO) database and data obtained through a systematic search of PubMed and Web of Science. The pooled odds ratio (OR) and hazard ratio (HR) with 95% CI (Confidence interval) were used to judge the value of biomarkers.
RESULTS
A total of 28 studies were included in this meta-analysis, comprising a total of 3573 patients. MALAT-1 was significantly linked with over survival (OS) (HR=1.58, 95%CI: 1.12-2.23), recurrence-free survival (RFS) (HR=2.32, 95% CI: 1.68-3.19) and death-free survival (DFS) (HR=3.28, 95% CI: 1.52-7.09). We found that MALAT-1 was a risk factor in the prognoses of lung cancer (HR=1.54, 95%CI: 1.01-2.34), digestive system cancer (HR=2.16, 95% CI: 1.34-3.48) and ovarian cancer (HR=3.98, 95% CI: 1.54-10.25). In contrast, MALAT-1 was a safe factor in the prognosis of B cell lineage cancer (HR=0.45, 95% CI: 0.33-0.61). MALAT-1 was also a risk factor of RFS in breast cancer (HR=1.97, 95% CI: 1.25-3.09) and the TNM stage in pancreatic cancer (OR=3.65, 95% CI: 1.86-7.18) and glioma (OR=4.30, 95% CI: 1.90-9.73) and was a safe factor in colorectal cancer (OR=0.17, 95% CI: 0.08-0.35). MALAT-1 was significantly associated with lymph node metastasis in clear cell carcinoma (OR=5.04, 95% CI: 2.36-10.78) and distant metastasis in pancreatic cancer (OR=11.64, 95% CI: 2.13-63.78).
CONCLUSIONS
MALAT-1 can serve as a molecular marker in different types of cancers.
背景
MALAT-1在多种癌症中显著过表达，提示其可能是一种潜在的癌症生物标志物。
方法
使用通过基因表达综合数据库（GEO）中Affymetrix人类基因组U133 Plus 2.0平台获得的微阵列数据以及通过对PubMed和科学网进行系统检索获得的数据进行荟萃分析。采用合并比值比（OR）和风险比（HR）及95%置信区间（CI）来判断生物标志物的价值。
结果
本荟萃分析共纳入28项研究，涉及3573例患者。MALAT-1与总生存期（OS）（HR=1.58，95%CI：1.12 - 2.23）、无复发生存期（RFS）（HR=2.32，95%CI：1.68 - 3.19）和无病生存期（DFS）（HR=3.28，95%CI：1.52 - 7.09）显著相关。我们发现MALAT-1是肺癌（HR=1.54，95%CI：1.01 - 2.34）、消化系统癌症（HR=2.16，95%CI：1.34 - 3.48）和卵巢癌（HR=3.98，95%CI：1.54 - 10.25）预后的危险因素。相比之下，MALAT-1是B细胞系癌症预后的安全因素（HR=0.45，95%CI：0.33 - 0.61）。MALAT-1也是乳腺癌RFS的危险因素（HR=1.97，95%CI：1.25 - 3.09）以及胰腺癌（OR=3.65，95%CI：1.86 - 7.18）和神经胶质瘤（OR=4.30，95%CI：1.90 - 9.73）TNM分期的危险因素，并且是结直肠癌的安全因素（OR=0.17，95%CI：0.08 - 0.35）。MALAT-1与透明细胞癌的淋巴结转移（OR=5.04，95%CI：2.36 - 10.78）和胰腺癌的远处转移（OR=11.64，95%CI：2.13 - 63.78）显著相关。
结论
MALAT-1可作为不同类型癌症的分子标志物。
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