Lindenberg Liza
Molecular Imaging Program, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA.
Adjunct Assistant Professor of Radiology/Assistant Professor of Medicine, F. Edward Hebert School of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD.
Theranostics. 2017 May 15;7(7):2065-2066. doi: 10.7150/thno.20622. eCollection 2017.
Diagnosing bone metastases with traditional anatomic modalities, such as MRI and CT, is limited by sensitivity, and conventional bone radiotracers are only indirect markers of cancer activity. Fortunately, molecular imaging is uniquely capable of providing radiotracers such as fluciclovine and radiolabeled choline, that actually target tumors in the bone. The merits of research in imaging osseous metastases in animal models using these radiotracers and the implications for future clinical translation are discussed.
使用传统解剖学方法（如MRI和CT）诊断骨转移受到敏感性的限制，而传统的骨放射性示踪剂只是癌症活性的间接标志物。幸运的是，分子成像能够独特地提供如氟代氯膦酸二钠和放射性标记胆碱等放射性示踪剂，这些示踪剂实际上能够靶向骨骼中的肿瘤。本文讨论了使用这些放射性示踪剂在动物模型中进行骨转移成像研究的优点以及对未来临床转化的意义。
