生长抑素与大脑皮层。

Somatostatin and the cerebral cortex.

作者信息

Robbins R

出版信息

Adv Exp Med Biol. 1985;188:201-15. doi: 10.1007/978-1-4615-7886-4_12.

Abstract

A unique subset of interneurons which are rich in immunoreactive somatostatin (IRS) exists in the cerebral cortex. The regulation of IRS secretion by these cells is reviewed. Acetylcholine, glutamic acid and several neuropeptides including VIP, CCK, and metenkephalin have been identified as IRS secretagogues. The types of molecules which stimulate IRS release, the electrophysiologic effects of somatostatin, and the recognition of abnormal IRS levels in human CNS diseases were all used to formulate a working model of the role of the somatostatinergic cell in ongoing cerebral cortical function.

摘要

大脑皮层中存在一类独特的中间神经元亚群，其富含免疫反应性生长抑素（IRS）。本文综述了这些细胞对IRS分泌的调节作用。已确定乙酰胆碱、谷氨酸以及包括血管活性肠肽（VIP）、胆囊收缩素（CCK）和甲硫氨酸脑啡肽在内的几种神经肽为IRS促分泌剂。刺激IRS释放的分子类型、生长抑素的电生理效应以及人类中枢神经系统疾病中异常IRS水平的识别，均被用于构建一个关于生长抑素能细胞在大脑皮层持续功能中作用的工作模型。