Pancreatic somatostatin.

This is a review of pancreatic somatostatin which is limited in its scope and therefore focuses upon some selected issues. Throughout the entire review the same basic questions recur: Why do islets contain somatostatin? What is the physiological role of somatostatin and what does this peptide have to do with diabetes? Clear answers to these questions do not emerge, but a number of hunches are explored. The review provides a very brief look at somatostatin secretion, a discussion of the potential interactions which islet D cells might have with other islet cell types, consideration of how knowledge of islet anatomy may help us understand the D cell, and finally some comments about what happens to the D cell in diabetes and fasting.