Han Wen-Yong, Zhao Jia, Wang Jian-Shu, Xiang Guang-Yan, Zhang Ding-Lei, Bai Mei, Cui Bao-Dong, Wan Nan-Wei, Chen Yong-Zheng
Generic Drug Research Center of Guizhou Province, School of Pharmacy, Zunyi Medical University, Zunyi, 563000, China.
Org Biomol Chem. 2017 Jul 5;15(26):5571-5578. doi: 10.1039/c7ob01266g.
An efficient [3 + 2] cycloaddition of 3-ylideneoxindoles with in situ generated CFHCHN for the syntheses of spirooxindoles has been developed. This methodology gives access to a range of relatively complex spirooxindoles featuring a CFH group and three contiguous stereogenic centers in up to 84% yield and 99 : 1 trans/cis.
已开发出一种3-亚甲吲哚与原位生成的CFHCHN进行高效的[3 + 2]环加成反应以合成螺环氧化吲哚的方法。该方法能够得到一系列相对复杂的螺环氧化吲哚，其具有一个CFH基团和三个相邻的手性中心，产率高达84%，反式/顺式比例为99:1。
