非选择性β受体阻滞剂预防肾上腺素诱导的低钾血症
Prevention of epinephrine-induced hypokalemia by nonselective beta blockers.
作者信息
Vincent H H, Man in't Veld A J, Boomsma F, Schalekamp M A
出版信息
Am J Cardiol. 1985 Aug 30;56(6):10D-14D. doi: 10.1016/0002-9149(85)91108-7.
PMID:2863970
Abstract
Experimental evidence is presented that activation of beta 2 adrenoreceptors causes a dose-dependent decrease in plasma potassium, probably by shifting potassium into the cell. By this mechanism epinephrine may cause hypokalemia and predispose to cardiac arrhythmias. Prevention of these effects by nonselective beta blockers may contribute to the cardioprotective action of these drugs.
摘要
实验证据表明，β2肾上腺素能受体的激活会导致血浆钾呈剂量依赖性降低，可能是通过将钾转移到细胞内实现的。通过这种机制，肾上腺素可能会导致低钾血症并易引发心律失常。非选择性β受体阻滞剂对这些效应的预防作用可能有助于这些药物的心脏保护作用。
Zotero 插件