Department of Chemistry, University of Cambridge , Lensfield Road, Cambridge CB2 1EW, United Kingdom.
J Am Chem Soc. 2017 Jul 12;139(27):9160-9163. doi: 10.1021/jacs.7b05340. Epub 2017 Jun 29.
A copper-catalyzed enantioselective arylative semipinacol rearrangement of allylic alcohols using diaryliodonium salts is reported. Chiral Cu(II)-bisoxazoline catalysts initiate an electrophilic alkene arylation, triggering a 1,2-alkyl migration to afford a range of nonracemic spirocyclic ketones with high yields, diastereo- and enantioselectivities.
本文报道了一种铜催化的对映选择性芳基烯丙醇重排反应，使用二芳基碘鎓盐。手性 Cu(II)-双恶唑啉催化剂引发亲电烯烃芳基化反应，引发 1,2-烷基迁移，以高收率、非对映选择性和对映选择性得到一系列非外消旋螺环酮。
