Asati Ankita, Satyanarayana G N V, Panchal Smita, Thakur Ravindra Singh, Ansari Nasreen G, Patel Devendra K
Academy of Scientific & Innovative Research (AcSIR), CSIR-IITR campus, Lucknow, India; Analytical Chemistry Laboratory, Regulatory Toxicology Group, CSIR-Indian Institute of Toxicology Research, Vishvigyan Bhawan, P. O. Box-80, M. G. Marg, Lucknow, 226001, Uttar Pradesh, India.
Analytical Chemistry Laboratory, Regulatory Toxicology Group, CSIR-Indian Institute of Toxicology Research, Vishvigyan Bhawan, P. O. Box-80, M. G. Marg, Lucknow, 226001, Uttar Pradesh, India; Department of Chemistry, School of Applied Sciences, Babu Banarasi Das University, Lucknow, 226028, Uttar Pradesh, India.
J Chromatogr A. 2017 Aug 4;1509:35-42. doi: 10.1016/j.chroma.2017.06.040. Epub 2017 Jun 16.
A sensitive, rapid and efficient ionic liquid-based vortex assisted liquid-liquid microextraction (IL-VALLME) with Liquid Chromatography Mass spectrometry (LC-MS/MS) method is proposed for the determination of bisphenols in thermal paper. Extraction factors were systematically optimized by response surface methodology. Experimental factors showing significant effects on the analytical responses were evaluated using design of experiment. The limit of detection for Bisphenol-A (BPA) and Bisphenol-S (BPS) in thermal paper were 1.25 and 0.93μgkg respectively. The dynamic linearity range for BPA was between 4 and 100μgkg and the determination of coefficient (R) was 0.996. The values of the same parameters were 3-100μgkg and 0.998 for BPS. The extraction recoveries of BPA and BPS in thermal paper were 101% and 99%. Percent relative standard deviation (% RSD) for matrix effect and matrix match effects were not more than 10%, for both bisphenols. The proposed method uses a statistical approach for the analysis of bisphenols in environmental samples, and is easy, rapid, requires minimum organic solvents and efficient.
本文提出了一种基于离子液体的灵敏、快速且高效的涡旋辅助液液微萃取（IL-VALLME）结合液相色谱-质谱联用（LC-MS/MS）的方法，用于测定热敏纸中的双酚。采用响应面法对萃取因素进行了系统优化。通过实验设计评估了对分析响应有显著影响的实验因素。热敏纸中双酚A（BPA）和双酚S（BPS）的检测限分别为1.25μg/kg和0.93μg/kg。BPA的动态线性范围为4至100μg/kg，测定系数（R）为0.996。BPS的相同参数值分别为3至100μg/kg和0.998。热敏纸中BPA和BPS的萃取回收率分别为101%和99%。两种双酚的基质效应和基质匹配效应的相对标准偏差（%RSD）均不超过10%。所提出的方法采用统计方法分析环境样品中的双酚，具有简便、快速、有机溶剂用量少且高效的特点。
