[化学致癌物的神经嗜性作用]
[Neurotropic action of chemical carcinogens].
作者信息
Klimenko E M, Sheveleva V S
出版信息
Eksp Onkol. 1985;7(4):23-6.
The effect of 4-dimethylaminoazobenzole, 4-diethylaminoazobenzole, 1,2-dimethylhydrazine and N-nitrosomethylurea on the synaptic transmission of impulses through the inferior mesenteric sympathetic ganglion is investigated in acute experiments with rats. It is found that irrespective of chemical structure of carcinogens and different specificity of their action on the various tissues-targets all these carcinogens inhibit the cholinergic ganglionic transmission. The inhibitory action of carcinogens may be connected with the excitement of presynaptic alpha-adrenoreceptors in sympathetic ganglia. Pyrroxane, an alpha-adrenoblocker, protects the synaptic transmission from the action of carcinogens.
在对大鼠进行的急性实验中，研究了4-二甲基氨基偶氮苯、4-二乙氨基偶氮苯、1,2-二甲基肼和N-亚硝基甲基脲对通过肠系膜下交感神经节的冲动突触传递的影响。结果发现，无论致癌物的化学结构如何，以及它们对各种组织靶点作用的不同特异性，所有这些致癌物都会抑制胆碱能神经节传递。致癌物的抑制作用可能与交感神经节中突触前α-肾上腺素能受体的兴奋有关。α-肾上腺素能阻滞剂吡咯烷能保护突触传递免受致癌物的作用。
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