Katz Heather, Saad Rahoma E, Denning Krista, Pacioles Toni O
Department of Hematology/Oncology, Joan C. Edwards School of Medicine, Marshall University, 1600 Medical Center Dr, Huntington, WV 25701, USA.
Department of Internal Medicine, Joan C. Edwards School of Medicine, Marshall University, 1600 Medical Center Dr, Huntington, WV 25701, USA.
Case Rep Gastrointest Med. 2017;2017:9343896. doi: 10.1155/2017/9343896. Epub 2017 May 31.
Metastatic esophageal adenocarcinoma to the urinary bladder is extremely rare. We describe a previously healthy 49-year-old female with recent diagnosis of adenocarcinoma of the gastroesophageal junction with metastatic disease to the liver. Biopsy was positive for human epidermal growth factor receptor 2 (HER2) by Fluorescence In Situ Hybridization (FISH). She received six cycles of Cisplatin, 5-Fluorouracil, and Herceptin and subsequently developed symptomatic anemia and hematuria. Cystoscopy with retroflexion was performed and she received a transurethral resection of bladder tumor with fulguration. Pathology of the bladder tumor revealed similar morphology to her liver metastasis and immunohistochemical stains were consistent with metastatic esophageal cancer. Three weeks after being diagnosed with metachronous urinary bladder metastasis from esophageal adenocarcinoma primary, she expired. She only received her first cycle of palliative chemotherapy with Ramucirumab and Paclitaxel.
膀胱转移性食管腺癌极为罕见。我们报告一名既往健康的49岁女性，近期诊断为胃食管交界腺癌伴肝转移。荧光原位杂交（FISH）检测显示人表皮生长因子受体2（HER2）活检呈阳性。她接受了六个周期的顺铂、5-氟尿嘧啶和赫赛汀治疗，随后出现症状性贫血和血尿。进行了膀胱镜逆行检查，并对她进行了膀胱肿瘤经尿道切除术及电灼术。膀胱肿瘤的病理显示其形态与肝转移灶相似，免疫组化染色结果与转移性食管癌一致。在被诊断为食管腺癌原发灶异时性膀胱转移三周后，她去世了。她仅接受了第一个周期的雷莫西尤单抗和紫杉醇姑息化疗。
