Le Dafniet M, Garnier P, Bression D, Brandi A M, Racadot J, Peillon F
Horm Metab Res. 1985 Sep;17(9):476-9. doi: 10.1055/s-2007-1013580.
Specific receptors for TRH were characterized on cellular membranes of 6 out of 13 somatotrophic adenomas obtained from acromegalic patients. These receptors had the same dissociation constant (Kd: 62 +/- 10 nM) as those found in human PRL-secreting adenomas, but their maximal number of binding sites (Bmax: 76 +/- 24 fmol/mg of protein) was six fold smaller. A good correlation was found between the presence of TRH receptors and the in vitro TRH-induced stimulation of GH secretion. The increase in GH release varied from 25 to 200%. It was thus concluded that these receptors are functional. However, why only some of the human somatotrophic adenomas possess TRH receptors and respond to TRH in vitro needs further investigations.
在从肢端肥大症患者身上获取的13个生长激素腺瘤中，有6个的细胞膜上鉴定出了促甲状腺激素释放激素（TRH）的特异性受体。这些受体的解离常数（Kd：62±10 nM）与在人类分泌催乳素的腺瘤中发现的受体相同，但其最大结合位点数（Bmax：76±24 fmol/mg蛋白质）小6倍。在TRH受体的存在与体外TRH诱导的生长激素分泌刺激之间发现了良好的相关性。生长激素释放的增加幅度在25%至200%之间。因此得出结论，这些受体是有功能的。然而，为什么只有一些人类生长激素腺瘤拥有TRH受体并在体外对TRH作出反应，这需要进一步研究。
