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[腹膜后纤维化的新(与旧)方面]

[New (and old) aspects of retroperitoneal fibrosis].

作者信息

Brandt A S, Dreger N M, Müller E, Kukuk S, Roth S

机构信息

Klinik für Urologie und Kinderurologie, Helios Universitätsklinikum Wuppertal, Lehrstuhl der Universität Witten/Herdecke, Heusnerstraße 40, 42285, Wuppertal, Deutschland.

Zentrum für Forschung in der klinischen Medizin (ZFKM) Wuppertal, Wuppertal, Deutschland.

出版信息

Urologe A. 2017 Jul;56(7):887-894. doi: 10.1007/s00120-017-0428-y.

Abstract

Retroperitoneal fibrosis (RPF) is an uncommon chronic inflammatory disease of the rear abdomen and it is commonly associated with the complication of uni- or bilateral hydronephrosis. Despite the rarity of this disease, multiple publications concerning etiology, diagnosis, therapy monitoring and both medical and surgical therapy have been published in recent years. Recent research has focused on asbestos exposure as a possible risk factor, the meaning of IgG4-associated RPF, measuring disease activity using different radiological and nuclear medicine procedures, and new approaches to medical therapy. Goals of treatment were characterized as the correct diagnosis, preservation of renal function and freedom from stents, steroids and pain. On the basis of these goals, the most important insights and developments of the last 5 years regarding RPF are presented.

摘要

腹膜后纤维化(RPF)是一种罕见的后腹部慢性炎症性疾病,通常伴有单侧或双侧肾积水并发症。尽管这种疾病罕见,但近年来已发表了多篇关于病因、诊断、治疗监测以及药物和手术治疗的文献。最近的研究集中在石棉暴露作为可能的危险因素、IgG4相关性RPF的意义、使用不同的放射学和核医学程序测量疾病活动度以及药物治疗的新方法。治疗目标被确定为正确诊断、保留肾功能以及无需使用支架、类固醇和止痛。基于这些目标,本文介绍了过去5年关于RPF的最重要见解和进展。

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