Lemley Kevin V
Department of Pediatrics, University of Southern California Keck School of Medicine, Los Angeles, CA, USA.
Division of Nephrology, Children's Hospital Los Angeles, 4650 Sunset Blvd, MS#40, Los Angeles, CA, 90027, USA.
Pflugers Arch. 2017 Aug;469(7-8):959-963. doi: 10.1007/s00424-017-2012-0. Epub 2017 Jun 22.
In this article, I shall outline some of the most important aspects of the evidentiary basis of the so-called Kriz model for the development of glomerular sclerosis, a model that we continue to modify to this day. In my mind, the most important findings include the fact that podocytes are generally post-mitotic cells, so that loss of a significant number for any cause leads to podocyte insufficiency. Another pivotal finding is that in many experimental models and in human disease, podocytes detach from the GBM as living cells. These facts, together with biomechanical deduction, have led to the ongoing evolution of the original Heidelberg model.
在本文中，我将概述所谓的肾小球硬化症发展的Kriz模型证据基础的一些最重要方面，该模型至今仍在不断修改。在我看来，最重要的发现包括足细胞通常是有丝分裂后细胞，因此任何原因导致大量足细胞丢失都会导致足细胞功能不全。另一个关键发现是，在许多实验模型和人类疾病中，足细胞作为活细胞从肾小球基底膜脱离。这些事实，再加上生物力学推导，导致了原始海德堡模型的不断演变。
