Uitdehaag Bernard, Kobelt Gisela, Berg Jenny, Capsa Daniela, Dalén Johan
MS Center Amsterdam, Department of Neurology, VU University Medical Center, Amsterdam, The Netherlands.
European Health Economics, Mulhouse, France.
Mult Scler. 2017 Aug;23(2_suppl):117-129. doi: 10.1177/1352458517708663.
To estimate the value of interventions in multiple sclerosis (MS) - where lifetime costs and outcomes cannot be observed - outcome data have to be combined with costs. This requires that cost data be regularly updated.
This study is part of a cross-sectional retrospective study in 16 countries collecting data on resource consumption and work capacity, health-related quality of life (HRQoL) and prevalent symptoms for patients with MS. Descriptive analyses are presented by level of severity, from the societal perspective, in EUR 2015.
A total of 382 patients (mean age: 54 years) participated in the Netherlands; 81% were below retirement age and of these, 31% were employed. Employment was inversely related to disease severity, and MS affected productivity at work for 82% of patients. Overall, 96% and 73% of patients experienced fatigue and cognitive difficulties, respectively, as a problem. Mean utility and annual costs were 0.744 and €23,100 at Expanded Disability Status Scale (EDSS) 0-3, 0.595 and €32,300 at EDSS 4-6.5, and 0.297 and €50,500 at EDSS 7-9. The mean cost of a relapse was estimated at €3000.
This study provides current data on MS in the Netherlands that are important for the development of health policies and to estimate the value of current and future treatments.
为了评估针对多发性硬化症（MS）的干预措施的价值（在无法观察到终身成本和结果的情况下），必须将结果数据与成本相结合。这就要求定期更新成本数据。
本研究是一项在16个国家开展的横断面回顾性研究的一部分，收集了MS患者的资源消耗、工作能力、健康相关生活质量（HRQoL）和常见症状的数据。从社会角度，按严重程度水平以2015年欧元呈现描述性分析结果。
荷兰共有382名患者（平均年龄：54岁）参与；81%未达到退休年龄，其中31%有工作。就业与疾病严重程度呈负相关，MS影响了82%患者的工作生产力。总体而言，分别有96%和73%的患者将疲劳和认知困难视为问题。在扩展残疾状态量表（EDSS）0 - 3级时，平均效用和年度成本分别为0.744和23,100欧元；在EDSS 4 - 6.5级时，为0.595和32,300欧元；在EDSS 7 - 9级时，为0.297和50,500欧元。一次复发的平均成本估计为3000欧元。
本研究提供了荷兰MS的当前数据，这些数据对于卫生政策的制定以及评估当前和未来治疗的价值非常重要。
