Honavar Santosh G, Manjandavida Fairooz P, Reddy Vijay Anand P
Centre for Sight, Hyderabad, Telangana, India.
Eye Cancer Services, Horus Specialty Eye Care, Bangalore, India.
Indian J Ophthalmol. 2017 Jun;65(6):435-442. doi: 10.4103/ijo.IJO_352_15.
Orbital extension is a major cause of death in children with retinoblastoma in the developing countries. Delayed detection and inappropriate management contribute to poor outcome. Conventional treatment including primary orbital exenteration or chemotherapy or radiotherapy alone result in mortality as high as 70%. The recent understanding on the role of sequential multimodal therapy with a combination of high-dose chemotherapy, followed by appropriate surgery, radiotherapy, and additional adjuvant chemotherapy has helped dramatically improve life salvage.
眼眶侵犯是发展中国家视网膜母细胞瘤患儿的主要死亡原因。检测延误和处理不当导致预后不良。传统治疗方法，包括单纯的原发性眼眶内容剜除术、化疗或放疗，死亡率高达70%。最近对序贯多模式治疗作用的认识，即采用大剂量化疗，随后进行适当的手术、放疗和额外的辅助化疗，已极大地提高了挽救生命的几率。
