糖皮质激素介导的抗病毒状态的建立与L929细胞中其他糖皮质激素诱导的生化活性同时发生。

Glucocorticoid-mediated establishment of an antiviral state coincident with other glucocorticoid-induced biochemical activities in L929 cells.

作者信息

Lancz G J, Hulick B A, Grasso R J, Skinner L

出版信息

J Gen Virol. 1985 Oct;66 ( Pt 10):2249-52. doi: 10.1099/0022-1317-66-10-2249.

Abstract

Incubation of L929 cells with three different glucocorticoids, hydrocortisone, dexamethasone and triamcinolone acetonide, rendered the cells unable to support plaque formation by several unrelated DNA and RNA viruses. The establishment of this antiviral state by dexamethasone coincided with an inhibition of cell growth and induction of glutamine synthetase activity. These steroid-mediated activities occurred only in cultures of L929 cells and not in cultures of rabbit skin or rat glioma cells.

摘要

用三种不同的糖皮质激素（氢化可的松、地塞米松和曲安奈德）培养L929细胞，导致这些细胞无法支持几种不相关的DNA和RNA病毒形成蚀斑。地塞米松建立这种抗病毒状态的同时，伴随着细胞生长的抑制和谷氨酰胺合成酶活性的诱导。这些类固醇介导的活性仅在L929细胞培养物中出现，而在兔皮肤或大鼠胶质瘤细胞培养物中未出现。