Department of Oral Health Sciences, Medical University of South Carolina, Charleston, SC, USA.
Orthod Craniofac Res. 2017 Jun;20 Suppl 1(Suppl 1):8-11. doi: 10.1111/ocr.12153.
It is suggested that craniosynostosis is caused by a heterogeneous set of effects including gene mutations, teratogenic exposure during critical periods of development and gene/environment interactions. Distinguishing between sufficient, additive and interactive effects is important to the study of gene/environment interactions and allows for segregation of environmental exposures effecting susceptible populations. Through the identification of sufficient and interactive effects, efforts in prevention of craniosynostosis may be successful. Here, we provide a brief review focusing on defining these categorized exposures and relevant literature that has interrogated gene/environment interactions for craniosynostosis.
有人认为，颅缝早闭是由包括基因突变、发育关键期致畸暴露以及基因-环境相互作用在内的一系列异质性因素引起的。区分充分、累加和交互作用对于基因-环境相互作用的研究很重要，并且可以区分影响易感人群的环境暴露效应。通过确定充分和交互作用，可以成功地预防颅缝早闭。在这里，我们提供了一个简要的综述，重点是定义这些分类暴露，并探讨了颅缝早闭的基因-环境相互作用的相关文献。
