Zhong Ke, Liu Zhan-Chi, Wang Jia-Lin, Liu Xu-Sheng
Hubei Key Laboratory of Genetic Regulation and Integrative Biology, School of Life Sciences, Central China Normal University, Wuhan, China.
Arch Insect Biochem Physiol. 2017 Sep;96(1). doi: 10.1002/arch.21402. Epub 2017 Jun 23.
In this study, we investigated the effect of the entomopathogenic fungus Nomuraea rileyi on Helicoverpa armigera cellular immune responses. Nomuraea rileyi infection had no effect on total hemocyte count (THC), but impaired hemocyte-mediated phagocytosis, nodulation, and encapsulation responses. Nomuraea rileyi infection led to a significant reduction in hemocyte spreading. An in vitro assay revealed that plasma from N. rileyi infected H. armigera larvae suppressed the spreading ability of hemocytes from naïve larvae. We infer that N. rileyi suppresses the cellular immune response of its host, possibly by secreting exogenous, cytotoxic compounds into the host's hemolymph.
在本研究中，我们调查了昆虫病原真菌莱氏野村菌对棉铃虫细胞免疫反应的影响。莱氏野村菌感染对总血细胞计数（THC）没有影响，但损害了血细胞介导的吞噬作用、结瘤和包囊反应。莱氏野村菌感染导致血细胞铺展显著减少。一项体外试验表明，来自感染莱氏野村菌的棉铃虫幼虫的血浆抑制了未感染幼虫血细胞的铺展能力。我们推断，莱氏野村菌可能通过向宿主血淋巴中分泌外源性细胞毒性化合物来抑制其宿主的细胞免疫反应。
