Bayrak Ayse O, Ulusoy Hasan, Bolat Necdet, Doğan Baki, Ozbenli Taner
*Department of Neurology, Faculty of Medicine, Ondokuz Mayis University †Medicana Samsun Hospital, Rheumatology, Canik, Samsun, Turkey.
Neurologist. 2017 Jul;22(4):144-146. doi: 10.1097/NRL.0000000000000132.
Multifocal motor neuropathy with conduction block (MMN-CB) is purely a motor neuropathy with progressive weakness that is characteristically caused by conduction blocks. Association with antiganglioside antibodies and a good response to immunomodulating therapies suggest an autoimmune etiology. In rare cases, MMN-CB has been reported as an adverse effect of infliximab, a tumor necrosis factor-α blocker. We present a case of MMN-CB due to infliximab in a 45-year-old man with psoriatic arthritis who was exposed to the drug for 2 years because of a delayed diagnosis. We emphasize the possibility of this adverse effect and the importance of detailed electrophysiological examinations, which is supported by a review of the literature.
多灶性运动神经病伴传导阻滞（MMN-CB）是一种纯粹的运动神经病，表现为进行性肌无力，其特征性病因是传导阻滞。与抗神经节苷脂抗体相关以及对免疫调节治疗反应良好提示自身免疫性病因。在罕见情况下，MMN-CB被报道为肿瘤坏死因子-α阻滞剂英夫利昔单抗的不良反应。我们报告一例45岁银屑病关节炎男性患者因英夫利昔单抗导致的MMN-CB病例，该患者因诊断延迟而使用该药2年。我们强调了这种不良反应的可能性以及详细电生理检查的重要性，文献综述也支持这一点。
