ACSF3 和 Mal（丙二酸）适应的线粒体。

ACSF3 and Mal(onate)-Adapted Mitochondria.

机构信息

Department of Pathology and Institute of Gerontology, University of Michigan, Ann Arbor, MI 48109, USA.

Ben May Department for Cancer Research, The University of Chicago, Chicago, IL 60637, USA.

出版信息

Cell Chem Biol. 2017 Jun 22;24(6):649-650. doi: 10.1016/j.chembiol.2017.06.004.

DOI:10.1016/j.chembiol.2017.06.004

PMID:28644952

Abstract

In this issue of Cell Chemical Biology, Bowman and colleagues show that the mitochondrial enzyme ACSF3 generates malonyl-CoA from malonate, in turn regulating metabolic flux and mitochondrial protein malonylation (Bowman et al., 2017). The study reveals a mechanism to generate mitochondrial malonyl-CoA and how this molecule impacts mitochondrial biology.

摘要

在本期《细胞化学生物学》中，鲍曼及其同事表明，线粒体酶 ACSF3 可将丙二酸盐转化为丙二酰辅酶 A，进而调节代谢通量和线粒体蛋白的丙二酰化（Bowman 等人，2017 年）。该研究揭示了一种生成线粒体丙二酰辅酶 A 的机制，以及该分子如何影响线粒体生物学。