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用于微小残留病（MRD）检测的核仁磷酸蛋白1（NPM1）？像热滴一样！

NPM1 for MRD? Droplet Like It's Hot!

作者信息

Wertheim Gerald B W, Bagg Adam

机构信息

Division of Hematopathology, Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.

Division of Hematopathology, Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.

出版信息

J Mol Diagn. 2017 Jul;19(4):498-501. doi: 10.1016/j.jmoldx.2017.04.008.

DOI:10.1016/j.jmoldx.2017.04.008
PMID:28645444
Abstract

This commentary highlights the article by Mencia-Trinchant et al that describes a novel digital PCR assay for sensitive detection of minimal residual disease in NPM1 mutated acute myeloid leukemia.

摘要

本述评重点介绍了门西亚 - 特里尚特等人的文章，该文章描述了一种用于灵敏检测NPM1突变型急性髓系白血病微小残留病的新型数字PCR检测方法。

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NPM1 for MRD? Droplet Like It's Hot!用于微小残留病（MRD）检测的核仁磷酸蛋白1（NPM1）？像热滴一样！
J Mol Diagn. 2017 Jul;19(4):498-501. doi: 10.1016/j.jmoldx.2017.04.008.
2
Minimal/Measurable Residual Disease Monitoring in -Mutated Acute Myeloid Leukemia: A Clinical Viewpoint and Perspectives.伴有突变的急性髓系白血病中的微小残留病监测：临床观点和展望。
Int J Mol Sci. 2018 Nov 6;19(11):3492. doi: 10.3390/ijms19113492.
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Minimal Residual Disease Monitoring of Acute Myeloid Leukemia by Massively Multiplex Digital PCR in Patients with NPM1 Mutations.采用大规模多重数字PCR对NPM1突变的急性髓系白血病患者进行微小残留病监测
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Monitoring of minimal residual disease in acute myeloid leukemia with frequent and rare patient-specific NPM1 mutations.采用频繁和罕见的患者特异性 NPM1 突变对急性髓系白血病进行微小残留病监测。
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Improved minimal residual disease detection by targeted quantitative polymerase chain reaction in Nucleophosmin 1 type a mutated acute myeloid leukemia.通过靶向定量聚合酶链反应改善核磷蛋白1 a型突变急性髓系白血病中微小残留病的检测
Genes Chromosomes Cancer. 2016 Oct;55(10):750-66. doi: 10.1002/gcc.22375. Epub 2016 Jun 24.
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Minimal residual disease detection in acute myeloid leukemia by mutant nucleophosmin (NPM1): comparison with WT1 gene expression.通过突变型核磷蛋白（NPM1）检测急性髓系白血病中的微小残留病：与WT1基因表达的比较
Clin Chim Acta. 2008 Sep;395(1-2):120-3. doi: 10.1016/j.cca.2008.05.021. Epub 2008 Jun 8.
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A novel quantitative assessment of minimal residual disease in patients with acute myeloid leukemia carrying NPM1 (nucleophosmin) exon 12 mutations.对携带核仁磷酸蛋白（NPM1）第12外显子突变的急性髓系白血病患者微小残留病的一种新型定量评估。
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Monitoring of minimal residual disease in NPM1-mutated acute myeloid leukemia: a study from the German-Austrian acute myeloid leukemia study group.NPM1 突变型急性髓系白血病微小残留病监测：德国-奥地利急性髓系白血病研究组的一项研究。
J Clin Oncol. 2011 Jul 1;29(19):2709-16. doi: 10.1200/JCO.2011.35.0371. Epub 2011 May 9.
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Digital droplet PCR-based absolute quantification of pre-transplant NPM1 mutation burden predicts relapse in acute myeloid leukemia patients.基于数字液滴 PCR 的移植前 NPM1 突变负担绝对定量可预测急性髓系白血病患者的复发。
Ann Hematol. 2018 Oct;97(10):1757-1765. doi: 10.1007/s00277-018-3373-y. Epub 2018 May 22.
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[Evaluation of methods for detection of NPM1 gene mutations in acute myeloid leukemia].[急性髓系白血病中NPM1基因突变检测方法的评估]
Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2011 Aug;19(4):999-1004.

引用本文的文献

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Blood Cancer Discov. 2024 Jan 8;5(1):8-20. doi: 10.1158/2643-3230.BCD-23-0144.
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Biomarkers in Acute Myeloid Leukemia: Leveraging Next Generation Sequencing Data for Optimal Therapeutic Strategies.急性髓系白血病中的生物标志物：利用下一代测序数据制定最佳治疗策略
Front Oncol. 2021 Sep 30;11:748250. doi: 10.3389/fonc.2021.748250. eCollection 2021.
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Minimal/Measurable Residual Disease Monitoring in -Mutated Acute Myeloid Leukemia: A Clinical Viewpoint and Perspectives.
伴有突变的急性髓系白血病中的微小残留病监测：临床观点和展望。
Int J Mol Sci. 2018 Nov 6;19(11):3492. doi: 10.3390/ijms19113492.
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Ultrasensitive Detection of Chimerism by Single-Molecule Molecular Inversion Probe Capture and High-Throughput Sequencing of Copy Number Deletion Polymorphisms.通过单分子分子反转探针捕获和高通量测序拷贝数缺失多态性进行嵌合体的超灵敏检测。
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