Dai Yaqi, Huang Kunlun, Zhang Boyang, Zhu Liye, Xu Wentao
Beijing Advanced Innovation Center for Food Nutrition and Human Health, College of Food Science and Nutritional Engineering, China Agricultural University, 100083, Beijing, China; Beijing Laboratory for Food Quality and Safety, College of Food Science and Nutritional Engineering, China Agricultural University, 100083, Beijing, China.
Beijing Advanced Innovation Center for Food Nutrition and Human Health, College of Food Science and Nutritional Engineering, China Agricultural University, 100083, Beijing, China; Beijing Laboratory for Food Quality and Safety, College of Food Science and Nutritional Engineering, China Agricultural University, 100083, Beijing, China; The Supervision, Inspection and Testing Center of Genetically Modified Organisms, Ministry of Agriculture, 100083, Beijing, China.
Food Chem Toxicol. 2017 Nov;109(Pt 1):683-689. doi: 10.1016/j.fct.2017.06.034. Epub 2017 Jun 20.
Aflatoxin B1 (AFB1) is widely distributed in nature, especially in a variety of food commodities. It is confirmed to be the most toxic of all the aflatoxins. The toxicity of AFB1 has been well investigated, and it may result in severe health problems including carcinogenesis, mutagenesis, growth retardation, and immune suppression. Epigenetic modifications including DNA methylation, histone modifications and regulation of non-coding RNA play an important role in AFB1-induced disease and carcinogenesis. To better understand the evidence for AFB1-induced epigenetic alterations and the potential mechanisms of the toxicity of AFB1, we conducted a review of published studies of AFB1-induced epigenetic alterations.
黄曲霉毒素B1（AFB1）在自然界中广泛分布，尤其是在各种食品中。它被确认为所有黄曲霉毒素中毒性最强的一种。AFB1的毒性已得到充分研究，它可能导致严重的健康问题，包括致癌、诱变、生长迟缓以及免疫抑制。包括DNA甲基化、组蛋白修饰和非编码RNA调控在内的表观遗传修饰在AFB1诱发疾病和致癌过程中发挥着重要作用。为了更好地了解AFB1诱发表观遗传改变的证据以及AFB1毒性的潜在机制，我们对已发表的关于AFB1诱发表观遗传改变的研究进行了综述。
