Nickel ions inhibit histone demethylase JMJD1A and DNA repair enzyme ABH2 by replacing the ferrous iron in the catalytic centers.
作者信息
Chen Haobin, Giri Nitai Charan, Zhang Ronghe, Yamane Kenichi, Zhang Yi, Maroney Michael, Costa Max
出版信息
J Biol Chem. 2017 Jun 23;292(25):10743. doi: 10.1074/jbc.A109.058503.
Abstract
摘要
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Nickel ions inhibit histone demethylase JMJD1A and DNA repair enzyme ABH2 by replacing the ferrous iron in the catalytic centers.镍离子通过取代催化中心的亚铁离子来抑制组蛋白去甲基化酶JMJD1A和DNA修复酶ABH2。
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