不同类型的孕前肥胖与特定围产期结局之间存在剂量反应关系。
A dose-response relation exists between different classes of pre-gravid obesity and selected perinatal outcomes.
作者信息
Trojner Bregar Andreja, Tul Nataša, Fabjan Vodušek Vesna, Verdenik Ivan, Lucovnik Miha, Janša Vid, Blickstein Isaac
机构信息
Division of Obstetrics and Gynecology, Department of Perinatology, University Medical Centre, Ljubljana, Slovenia.
Department of Obstetrics and Gynecology, Kaplan Medical Center, Rehovot, Israel Affiliated with the Hadassah-Hebrew University School of Medicine, Jerusalem, Israel.
出版信息
Arch Gynecol Obstet. 2017 Sep;296(3):465-468. doi: 10.1007/s00404-017-4441-6. Epub 2017 Jun 23.
OBJECTIVE
To examine if a "dose-response" relation exists between different classes of pre-gravid obesity and selected perinatal outcomes.
METHODS
We evaluated 16,566 obese mothers, including 12,064 (72.8%), 3410 (20.6%), and 1092 (6.6%) with obesity class I, II, and III, respectively. We compared maternal age, primiparity, gestational age at birth, birth weight, GDM, hypertensive disorders, and the incidence of cesarean sections.
RESULTS
There was a significantly increased incidence (from class I to class III) for GDM (8.5-14.4%), chronic hypertension (2.8-9.0%), gestational hypertension (6.7-14.2%), and for preeclampsia (5.3-9.3%). No such relationship existed for birth weight and gestational duration.
CONCLUSION
Classes of obesity during pregnancy exhibit a "dose-response" relationship with maternal morbidity, but no such relationship was found with pregnancy duration and birth weight.
目的
研究不同孕期肥胖类别与选定的围产期结局之间是否存在“剂量反应”关系。
方法
我们评估了16566名肥胖母亲，其中分别有12064名（72.8%）、3410名（20.6%）和1092名（6.6%）为I、II和III级肥胖。我们比较了产妇年龄、初产情况、出生时的孕周、出生体重、妊娠期糖尿病（GDM）、高血压疾病以及剖宫产发生率。
结果
GDM（8.5%-14.4%）、慢性高血压（2.8%-9.0%）、妊娠期高血压（6.7%-14.2%）和先兆子痫（5.3%-9.3%）的发生率从I级到III级显著增加。出生体重和孕周不存在这种关系。
结论
孕期肥胖类别与产妇发病率呈现“剂量反应”关系，但未发现与孕期时长和出生体重存在这种关系。
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