Department of Infectious Diseases, University of Georgia, Athens, GA, 30602, USA.
Curr Top Microbiol Immunol. 2018;419:215-241. doi: 10.1007/82_2017_32.
Analysis of host gene expression profiles following viral infections of target cells/tissues can reveal crucial insights into the host: virus interaction and enables the development of novel therapeutics and prophylactics. Regions of the host genome that do not code for protein, encode structural, and functional non-coding RNAs that are important not only in regulation of host gene expression but also may impact viral replication. This review summarizes the role of host non-coding RNAs during replication of multiple respiratory viruses with a focus on Respiratory Syncytial Virus (RSV), an important pediatric pathogen. This review highlights the current state of knowledge and understanding regarding the function(s) of ncRNAs for respiratory viral infection and host immunity in general.
分析宿主基因表达谱在病毒感染靶细胞/组织后，可以深入了解宿主与病毒的相互作用，并为新型治疗药物和预防药物的开发提供依据。宿主基因组中不编码蛋白质的区域编码结构和功能非编码 RNA，这些 RNA 不仅在调节宿主基因表达方面很重要，还可能影响病毒的复制。本综述总结了宿主非编码 RNA 在多种呼吸道病毒复制过程中的作用，重点介绍了呼吸道合胞病毒（RSV），这是一种重要的儿科病原体。本综述强调了目前对 ncRNA 在呼吸道病毒感染和宿主免疫中的功能的认识和理解。
