Institute of Advanced Synthesis, School of Chemistry and Molecular Engineering, Jiangsu National Synergetic Innovation Center for Advanced Materials, Nanjing Tech University, 30 South Puzhu Road, Nanjing, 211816, P.R. China.
Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University, 21 Nanyang Link, Singapore, 637371, Singapore.
Angew Chem Int Ed Engl. 2017 Aug 7;56(33):9872-9876. doi: 10.1002/anie.201705321. Epub 2017 Jul 13.
A Pd-catalyzed fluoroarylation of gem-difluoroalkenes with aryl halides is reported. By taking advantage of the in situ generated α-CF -benzylsilver intermediates derived from the nucleophilic addition of silver fluoride to gem-difluoroalkenes, this strategy bypasses the use of a strong base, thus enabling a mild and general synthetic method for ready access to non-symmetric α,α-disubstituted trifluoroethane derivatives.
报道了钯催化的偕二氟烯烃与芳基卤化物的氟芳基化反应。通过利用氟化银的亲核加成反应原位生成的α-CF3-苯甲基银中间体，该策略避免了强碱的使用，从而为制备非对称α,α-二取代三氟乙烷衍生物提供了一种温和且通用的合成方法。
