University of Michigan, Department of Pediatrics and Communicable Disease, Division of Nephrology, Ann Arbor, Michigan, USA.
University of Michigan, Department of Pediatrics and Communicable Disease, Division of Nephrology, Ann Arbor, Michigan, USA.
Kidney Int. 2017 Jul;92(1):21-23. doi: 10.1016/j.kint.2017.02.029.
Management of idiopathic nephrotic syndrome in children is based on a series of clinical trials. The trial by Sinha and colleagues in this issue is 1 of many needed to improve the evidence base for induction and maintenance therapies in this population. While key questions remain about identifying the appropriate therapy for each patient, clinical trials provide an opportunity to extend evidence-based practice that minimizes toxicity and optimizes patient health.
儿童特发性肾病综合征的治疗主要基于一系列临床试验。本期 Sinha 等的研究是众多此类临床试验中的一项，旨在为该人群的诱导缓解和维持治疗提供更多的循证医学证据。尽管对于如何为每位患者选择合适的治疗方案，仍存在一些关键问题有待解答，但临床试验为扩展基于证据的临床实践提供了机会，使治疗方案毒性最小化并使患者获益最大化。
