Garcha H S, Rose I C, Stolerman I P
Psychopharmacology (Berl). 1985;87(2):233-7. doi: 10.1007/BF00431814.
Some characteristics of the discriminative stimulus (cue) effects of midazolam, a short-acting benzodiazepine, have been determined in rats. A standard two-bar operant conditioning procedure with food reinforcers delivered on a tandem schedule was used. The 0.4 mg/kg dose of midazolam used for training was well discriminated, typically yielding at least 95% correct responding. Other benzodiazepines increased the percentage of drug-appropriate responding in a dose-related manner and were generalized at doses which had little effect on the overall rate of responding. Doses of pentobarbitone which greatly reduced the overall rate of responding were also generalized with midazolam. Amphetamine, oxotremorine, picrotoxin, morphine, nicotine, quipazine and Ro 15-1788 were not generalized, even at doses which severely suppressed overall response rates. The midazolam cue possesses a considerable degree of specificity and provides a potentially useful assay for drug action at the benzodiazepine receptor complex.
已在大鼠中确定了短效苯二氮䓬类药物咪达唑仑的辨别刺激（线索）效应的一些特征。采用了标准的双杆操作性条件反射程序，食物强化物按串联时间表给予。用于训练的0.4mg/kg剂量的咪达唑仑得到了很好的辨别，通常产生至少95%的正确反应。其他苯二氮䓬类药物以剂量相关的方式增加了药物适当反应的百分比，并且在对总体反应率影响很小的剂量下出现泛化。大大降低总体反应率的戊巴比妥剂量也与咪达唑仑产生泛化。即使在严重抑制总体反应率的剂量下，苯丙胺、毒扁豆碱、印防己毒素、吗啡、尼古丁、喹哌嗪和Ro 15-1788也不会产生泛化。咪达唑仑线索具有相当程度的特异性，并为苯二氮䓬受体复合物处的药物作用提供了一种潜在有用的测定方法。
