Vécsei L, Kovács G L, Faludi M, Bollók I, Telegdy G
Acta Physiol Hung. 1985;66(2):213-7.
The dose-related effects of cysteamine treatment on hypothalamic and striatal neurotransmission were investigated. Cysteamine pretreatment with a dose of 150 mg/kg slightly increased the dopamine, and markedly decreased the noradrenaline, content of the hypothalamus in a dose-related manner. The serotonin levels of the hypothalamus and striatum were not affected. Cysteamine pretreatment with a higher dose (300 mg/kg sc) slightly increased the uptake of noradrenaline into hypothalamic slices. The drug did not influence dopamine and serotonin uptake into hypothalamus and striatal slices. These results suggest that cysteamine decreases rather selectively the noradrenaline content of the hypothalamus.
研究了半胱胺治疗对下丘脑和纹状体神经传递的剂量相关效应。150mg/kg剂量的半胱胺预处理以剂量相关的方式使多巴胺略有增加，并使下丘脑去甲肾上腺素含量显著降低。下丘脑和纹状体的5-羟色胺水平未受影响。更高剂量（300mg/kg皮下注射）的半胱胺预处理使下丘脑切片中去甲肾上腺素的摄取略有增加。该药物不影响多巴胺和5-羟色胺摄取进入下丘脑和纹状体切片。这些结果表明，半胱胺相当有选择性地降低下丘脑的去甲肾上腺素含量。
