[Relationship between pesticide exposure and adverse pregnancy outcomes among reproductive couples in rural areas of China].

To analyze the association between pesticide exposure and adverse pregnancy outcomes in women from the rural areas of China. Data of "National Free Preconception Health Examination Project (NFPHEP)" from January 2010 to December 2012 was used for analysis. A total of 248 501 families that were planning to deliver a baby in the next 6 months were enrolled. Data on paternal exposure to pesticides before or during pregnancy was collected through questionnaires, with related outcomes on pregnancy recorded by doctors. Among all the 248 501 participants, 1 806 (0.74) women and 2 653 (1.09) men reported to have been exposed to pesticide before pregnancy, with 505 (0.21) reported of having been exposed to pesticide during the period of pregnancy. Maternal exposure to pesticide was found a risk factor related to stillbirth (=3.37, 95: 2.05-5.55), peculiar smell pregnancy (=3.17, 95:1.18-8.55) and low birth weight (=7.56, 95: 5.36-10.66). Paternal exposure to pesticide was also found related to miscarriage (=1.37, 95: 1.03-1.80), low birth weight (=3.65, 95:1.51-8.84), or giant infant (=0.64, 95: 0.44-0.93). Maternal exposure to pesticide during pregnancy appeared a risk factor on miscarriage (=4.65, 95: 3.47-6.24). Other adverse outcomes on pregnancy would include premature birth and high birth weight. Parental pesticide exposure appeared a risk factor on stillbirth, peculiar smell pregnancy, low birth weight and miscarriage.