Iskandrian A S, Hakki A H, Laddu A
Am J Cardiol. 1985 Oct 23;56(11):27F-32F. doi: 10.1016/0002-9149(85)90913-0.
In a double-blind, randomized, crossover study, the effects of esmolol and propranolol were examined at rest and during peak upright exercise in 15 patients. At rest, both esmolol and propranolol significantly decreased heart rate, systolic blood pressure, rate-pressure product, left ventricular ejection fraction, cardiac index and right ventricular ejection fraction. During exercise, significant decreases were also found in heart rate, systolic blood pressure and cardiac index in both treatment groups. No significant differences were found between mean esmolol and mean propranolol measurements at rest and during exercise, except for the exercise systolic blood pressure, which was lower during esmolol infusion. Blood levels of esmolol decreased markedly by 30 minutes postinfusion, as did its beta-blocking action. Esmolol was well tolerated with no important local, systemic or laboratory abnormalities. Thus, the effects of esmolol on cardiovascular performance at rest and during exercise are similar to those of propranolol.
在一项双盲、随机、交叉研究中，对15名患者在静息状态和直立运动高峰时艾司洛尔和普萘洛尔的作用进行了检查。静息时，艾司洛尔和普萘洛尔均显著降低心率、收缩压、心率-血压乘积、左心室射血分数、心脏指数和右心室射血分数。运动期间，两个治疗组的心率、收缩压和心脏指数也显著降低。除了运动收缩压在输注艾司洛尔期间较低外，静息和运动时艾司洛尔的平均测量值与普萘洛尔的平均测量值之间未发现显著差异。输注后30分钟，艾司洛尔的血药浓度显著下降，其β受体阻滞作用也随之下降。艾司洛尔耐受性良好，无重要的局部、全身或实验室异常。因此，艾司洛尔在静息和运动时对心血管功能的影响与普萘洛尔相似。
