Department of Psychiatry, Jagiellonian University, Medical College, Kraków, Poland.
Department of Psychophysiology, Faculty of Psychology, Jagiellonian University, Kraków, Poland; Inserm U 1127, CNRS UMR 7225, Sorbonne Universités, UPMC Univ Paris 06 UMR S 1127, Institut du Cerveau et de la Moelle épinière, ICM, F-75013 Paris, France.
Prog Neuropsychopharmacol Biol Psychiatry. 2017 Oct 3;79(Pt B):169-175. doi: 10.1016/j.pnpbp.2017.06.025. Epub 2017 Jun 23.
Impairment of implicit motor sequence learning was shown in schizophrenia (SZ) and, most recently, in bipolar disorder (BD), and was connected to cerebellar abnormalities. The goal of this study was to compare implicit motor sequence learning in BD and SZ.
We examined 33 patients with BD, 33 patients with SZ and 31 healthy controls with a use of ambidextrous Serial Reaction Time Task (SRTT), which allows exploring asymmetries in performance depending on the hand used.
BD and SZ patients presented impaired implicit motor sequence learning, although the pattern of their impairments was different. While BD patients showed no signs of implicit motor sequence learning for both hands, the SZ group presented some features of motor learning when performing with the right, but not with the left hand.
To our best knowledge this is the first study comparing implicit motor sequence learning in BD and SZ. We show that both diseases share impairments in this domain, however in the case of SZ this impairment differs dependently on the hand performing SRTT. We propose that implicit motor sequence learning impairments constitute an overlapping symptom in BD and SZ and suggest further neuroimaging studies to verify cerebellar underpinnings as its cause.
在精神分裂症（SZ）和最近的双相情感障碍（BD）中，都显示出内隐运动序列学习受损，并且与小脑异常有关。本研究的目的是比较 BD 和 SZ 中的内隐运动序列学习。
我们使用双手交替序列反应时任务（SRTT）检查了 33 名 BD 患者、33 名 SZ 患者和 31 名健康对照者，该任务允许根据使用的手来探索表现的不对称性。
BD 和 SZ 患者都表现出内隐运动序列学习受损，尽管他们的损伤模式不同。虽然 BD 患者双手都没有内隐运动序列学习的迹象，但 SZ 组在使用右手时表现出一些运动学习的特征，但左手则没有。
据我们所知，这是首次比较 BD 和 SZ 中的内隐运动序列学习的研究。我们表明，这两种疾病在该领域都存在损伤，但在 SZ 中，这种损伤取决于执行 SRTT 的手而有所不同。我们提出，内隐运动序列学习损伤构成了 BD 和 SZ 的重叠症状，并建议进一步进行神经影像学研究以验证小脑基础作为其原因。
