Galletly D C, Treuren B C
Anaesth Intensive Care. 1985 Aug;13(3):305-10. doi: 10.1177/0310057X8501300311.
Using an ordinal measure of cutaneous sensitivity to intradermal injections of atracurium and vecuronium, 40 nonreacting subjects were compared with a group of 24 patients previously suffering life-threatening anaphylactoid reactions to other muscle relaxants. Enhanced cutaneous sensitivity to vecuronium was found in three, and to atracurium in two of the previously reacting group. With the exception of those showing abnormal reactivity, no significant difference was found in the distribution of cutaneous sensitivity in the control and reacting group. A concentration of vecuronium 8.75 times that of atracurium was required to produce an equivalent intradermal wheal response.
采用对皮内注射阿曲库铵和维库溴铵的皮肤敏感性的序贯测量方法，将40名无反应受试者与一组24名先前对其他肌肉松弛剂发生过危及生命的类过敏反应的患者进行比较。在先前有反应的组中，发现3人对维库溴铵的皮肤敏感性增强，2人对阿曲库铵的皮肤敏感性增强。除了那些表现出异常反应性的受试者外，对照组和有反应组的皮肤敏感性分布没有显著差异。产生同等皮内风团反应所需的维库溴铵浓度是阿曲库铵浓度的8.75倍。
