Rostami Hadiseh Nowparast, Saville Christopher W N, Klein Christoph, Ouyang Guang, Sommer Werner, Zhou Changsong, Hildebrandt Andrea
Department of Psychology, Humboldt-University at Berlin, Germany; Department of Physics, Centre for Nonlinear Studies, Institute of Computational and Theoretical Studies, Hong Kong Baptist University, Kowloon Tong, Hong Kong.
School of Psychology, Bangor University, Wales, United Kingdom.
Biol Psychol. 2017 Jul;127:209-219. doi: 10.1016/j.biopsycho.2017.06.002. Epub 2017 Jun 23.
Previous research on the association between intra-subject variability (ISV) in reaction times (RTs) and the ValMet polymorphism of the catechol-o-methyltransferase gene (COMT; rs4680) has yielded mixed results. The present study compared the associations between COMT genotype and ISV in P3b latency measured during working and secondary memory tasks using residue iteration decomposition (RIDE) of single trial latencies. We compared the outcome of the present analyses with a previous analysis of the same data (N=70, n-back tasks) using an alternative single-trial method. Additionally, we used RIDE to analyse the association between COMT genotype and ISV in an independent sample performing a different task (N=91, face-recognition task). Analyses reconfirmed previous results from the n-back tasks, showing that Val alleles are associated with lower ISV. In the face recognition tasks, genotype interacted with task conditions, so Val homozygotes had higher ISV to unfamiliar faces than familiar ones but Met carriers showed no effect of familiarity. Moreover, in both datasets trial-by-trial RTs were predicted by P3b latencies. Therefore, the present data suggests that associations between COMT genotype and ISV depend on the type of cognitive processes, which may explain heterogeneity in previous results.
先前关于反应时间（RT）的受试者内变异性（ISV）与儿茶酚-O-甲基转移酶基因（COMT；rs4680）的缬氨酸-蛋氨酸多态性之间关联的研究结果不一。本研究使用单次试验潜伏期的残差迭代分解（RIDE），比较了工作和情景记忆任务期间测量的P3b潜伏期的COMT基因型与ISV之间的关联。我们将本分析结果与之前使用另一种单次试验方法对相同数据（N = 70，n-back任务）进行的分析结果进行了比较。此外，我们使用RIDE分析了执行不同任务的独立样本（N = 91，面部识别任务）中COMT基因型与ISV之间的关联。分析再次证实了n-back任务的先前结果，表明缬氨酸等位基因与较低的ISV相关。在面部识别任务中，基因型与任务条件相互作用，因此缬氨酸纯合子对不熟悉面孔的ISV高于熟悉面孔，但蛋氨酸携带者则没有表现出熟悉度的影响。此外，在两个数据集中，逐次试验的RT由P3b潜伏期预测。因此，目前的数据表明，COMT基因型与ISV之间的关联取决于认知过程的类型，这可能解释了先前结果中的异质性。
