Akazawa Hiroshi
Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo, Japan.
Clin Calcium. 2017;27(7):963-968.
Chronic inflammation is one of the common pathological bases underlying aging and aging-related diseases. Recently, it was reported that complement C1q, a crucial regulator of innate immunity, is deeply involved in the pathogenesis of aging-related sarcopenia, heart failure, and hypertension-induced aortic remodeling. In this review, the role and function of chronic inflammation in aging and aging-related diseases will be summarized.
慢性炎症是衰老及衰老相关疾病的常见病理基础之一。最近有报道称，补体C1q作为固有免疫的关键调节因子，深度参与衰老相关的肌肉减少症、心力衰竭和高血压诱导的主动脉重塑的发病机制。在本综述中，将总结慢性炎症在衰老及衰老相关疾病中的作用和功能。
