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Mammalian heart renewal by pre-existing cardiomyocytes.哺乳动物的心肌再生由预先存在的心肌细胞完成。
Nature. 2013 Jan 17;493(7432):433-6. doi: 10.1038/nature11682. Epub 2012 Dec 5.
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Multi-isotope imaging mass spectrometry quantifies stem cell division and metabolism.多同位素成像质谱定量分析干细胞分裂和代谢。
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Multi-isotope imaging mass spectrometry reveals slow protein turnover in hair-cell stereocilia.多同位素成像质谱法揭示了毛细胞静纤毛中缓慢的蛋白质周转。
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Increased turnover of T lymphocytes in HIV-1 infection and its reduction by antiretroviral therapy.HIV-1感染中T淋巴细胞周转率增加及其通过抗逆转录病毒疗法的降低。
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在NanoSIMS50L上使用七个探测器准同时采集九种二次离子:应用于生物样品。

Quasi-simultaneous acquisition of nine secondary ions with seven detectors on NanoSIMS50L: application to biological samples.

作者信息

Guillermier Christelle, Steinhauser Matthew L, Lechene Claude P

机构信息

Division of Genetics, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

National Resource for Imaging Mass Spectrometry (NRIMS), Cambridge, MA, USA.

出版信息

Surf Interface Anal. 2014 Nov;46(Suppl 1):150-153. doi: 10.1002/sia.5496. Epub 2014 May 7.

DOI:10.1002/sia.5496
PMID:28649151
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5482274/
Abstract

We employed a method of electrostatic peak switching allowing for the quasi-simultaneous measurement of O, O, CH, CD,CN, CN, CN, P, and S with the NanoSIMS 50L instrument to derive ratios for D/H, C/C, O/O, and N/N from biological samples. This approach involves two steps: (i) derivation of the D/H ratio from measurements of CD and CH and (ii) switching of the voltage on deflection plates located in front of two detectors. The method is reliable and easy to set up compared with the magnetic peak-switching mode usually used to perform this type of analysis.

摘要

我们采用了一种静电峰切换方法,通过NanoSIMS 50L仪器对O、O、CH、CD、CN、CN、CN、P和S进行准同步测量,以从生物样品中得出D/H、C/C、O/O和N/N的比率。该方法包括两个步骤:(i) 通过测量CD和CH得出D/H比率;(ii) 切换位于两个探测器前方的偏转板上的电压。与通常用于进行此类分析的磁峰切换模式相比,该方法可靠且易于设置。